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Research in the field of extracellular vesicles (EVs) is challenged by the small size of the nano-sized particles. Apart from the use of transmission and scanning electron microscopy, established technical platforms to visualize, quantify, and characterize nano-sized EVs were lacking.

2 iebel C, etal M Open 2199e222 doi11136bmjopen21222 Open access been linked to higher A&E attendance rates in past research.3 6–11 Previous studies on predictors of A&E attendance have been limited because they have not assessed the

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